CHAPTER VI
EFFICIENCY OF RADIUM IN TREATMENT OF VARIOUS DISEASES
In 1923, Dr. R. E. Loucks, president of the American Radium Society, announced that toxic goiter had been cured by radium. Exophthalmic goiter has been, in most cases, successfully treated by irradiation. Just how the cure is effected is still unknown; for the thyroid body from animals exposed for many hours to the Gamma irradiations of radium bromide shows no perceptible histological changes. Yet far less radiation produces marked changes in the tadpoles derived from normal ova fertilized by spermatazoa which have been radiated in the frog, though no testicular changes can be detected with certainty (Encyclopaedia Britannica, Vol. 32, p. 224, 12th Ed.).
Among other diseases which have been more or less successfully treated by radium may be mentioned lupus vulgarus, epithelial tumors, syphilitic ulcers, chronic itching of the skin, papillomata (an epithelial tumor formed by hypertrophy of the papillae of the skin or mucuous membrane, as a corn or a wart), angiomata (tumor composed chiefly of dilated blood or lymph vessels), pigmentary naevi (blemish of the skin due to pigment, as a birth-mark), and pruritus (itching). Radium has been particularly effective in treating serious affections of the eyes, as was first fully demonstrated by Dr. Walter S. Franklin and Frederick C. Cordes, of San Francisco.
The most brilliant successes of radium have been in those cases “where some serious complicating ailment, such as heart disease, tuberculosis, Bright’s disease, or an extreme anemia, contra-indicates anesthesia or any procedure which will tax the patient’s vital resources; radium steps in and does its work quietly, imperceptibly and, indeed, without the slightest risk to life.”
Dr. Howard A. Kelly, of Johns Hopkins University, has been very successful in curing swollen masses of glands on the sides of the neck, cancer of the thyroid and of the cervix, and sarcoma of the chest. Dr. E. S. Molyneaux of London, has cured obdurate cases of tubercular glands in the neck, a disease rather frequent among children. Thanks to the patient researches of Dr. John A. Marshall, associate professor of biochemistry and dental pathology at the University of California, it is now known that a radioactive liquid may be used for sterilizing infected tissue. Experiments employing the radioactive liquid in the treatment of root canals have been conducted at the George Williams Hooper Foundation for Medical Research and at the College of Dentistry of the University of California.
Within the time that the new antiseptic has been in use at these colleges, 85% of all the cases treated have been successful; and, with one exception, no soreness or pain has followed its use. This radioactive preparation is a solution of radium salts, “Radium D plus E,” which results from the decomposition of radium emanation, which, readily soluble in water, possesses definite radioactive properties. In making the solution the tiny capillary tubes containing the decomposed radium are crushed under water in a mortar and the liquid is then ready for use in the treatment of an ulcerated root of a tooth.
Dr. Marshall had been working with radium for months before admitting the success of his investigations, which were conducted in a long series of experiments on the lower animals. “Microscopic examinations of abscessed tissue,” he said, “which have been treated with radioactive solutions, indicate that the bacteria producing the affection were killed. And in no cases observed has the treatment produced radium burns; the amounts used have been too small and the effects of too transitory a nature. That sterilization of tissue can be produced, however, seems apparent.
“The discovery is purely of academic interest because of the fact that radium is too expensive, and it is possible to obtain it only in limited quantities; so that the chief value of the discovery will rest in the fact that it will stimulate further work for the identification of more accessible material.”
In external treatment by radium itself, emanations from a certain quantity of radium are allowed to focus on parts of the body over the diseased organs. Thus the curative functions of the diseased portion are stimulated to activity. The atrophying of diseased tonsils has been the most successful use of this form of treatment.
In the destruction of disease germs the radium emanation has been found more useful than the direct rays. The emanations kill or check the growth of anthrax, typhoid, and diphtheric germs. The direct rays are efficient in the relief of severe cases of enurites and facial neuralgia, cancer, tumors, affections of the skin and abnormal growths. Dr. Guyenot has proved that radium effects a complete cure for rheumatism, which he accounts for in these words: “Uric acid circulates in the blood in the form of urate of soda, of which there are two isomeric forms differing from each other by their respective solubility in the blood plasms. The soluble salt is converted into an insoluble form.” Radium breaks up this compound. The “rheumatism” disappears.